Isotopic Effect on Ion Mobility and Separation of Isotopomers by High-Field Ion Mobility Spectrometry

Isotopic effect on ion mobility and separation of isotopomers by high-field ion mobility spectrometry.

Distinguishing and separating isotopic molecular variants is important across many scientific fields. However, discerning such variants, especially those producing no net mass difference, has been challenging. For example, single-stage mass spectrometry is broadly employed to analyze isotopes but is blind to isotopic isomers (isotopomers) and, except at very high resolution, species of the same...

DETECTION AND MEASUREMENT OF ACETONE IN THE BREATH OF DIABETICS BY ION MOBILITY SPECTROMETRY METHOD

Background: The ion mobility spectrometry (IMS) is an analytical technique that is widely used due to its high sensitivity and speed for the detection of ionized molecules in gas phase and under atmospheric pressure. Breath analysis is a new method for obtaining information about person's clinical conditions that is considered by researchers. Human exhaled air contains a variety of components s...

Separation and Identification of Isomeric Glycopeptides by High Field Asymmetric Waveform Ion Mobility Spectrometry

The analysis of intact glycopeptides by mass spectrometry is challenging due to the numerous possibilities for isomerization, both within the attached glycan and the location of the modification on the peptide backbone. Here, we demonstrate that high field asymmetric wave ion mobility spectrometry (FAIMS), also known as differential ion mobility, is able to separate isomeric O-linked glycopepti...

Ion Mobility Mass Spectrometry

for more complex analysers for automated sample processing and plant control. The separation time will continue to decrease; in the past there has been limited interest in fast separations but this could change as automated sample processing is developed. Increasing use of coupled techniques such as GC-GC, liquid chromatography-GC, and supercritical Suid chromatography-GC for the separation of ...

Ion Mobility-Mass Spectrometry